At this page, you will find a list of publications based on research performed as part of the IMGENE project.

Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Xiaoyu Chen, Francesca Tasca, Qian Wang, Jin Liu, Josephine M Janssen, Marcella D Brescia, Milena Bellin, Karoly Szuhai, Josefin Kenrick, Richard L Frock, Manuel A F V Gonçalves

Nucleic Acids Research

Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery

Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca

Nature Communications

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events
Josephine M. Janssen, Xiaoyu Chen, Jin Liu, Manuel A.F.V. Gonçalves

Molecular Therapy - Nucleic Acids


A primer to gene therapy: Progress, prospects, and problems
Hidde A. Zittersteijn, Manuel A.F.V. Gonçalves, Rob C. Hoeben

Journal of Inherited Metabolic Disease

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny
Francesca Tasca, Qian Wang, Manuel A.F.V. Gonçalves


CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review
Syding, Linn Amanda; Nickl, Petr; Kasparek, Petr; Sedlacek, Radislav

Volume: 9 Issue: 4 Article Number: 993

Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?
Nadja Bischoff, Sandra Wimberger, Marcello Maresca, Cord Brakebusch


DNA Damage: From Threat to Treatment
Antonio Carusillo, Claudio Mussolino

Cells 9/7
doi: 10.3390/cells9071665

A versatile reporter system for multiplexed screening of effective epigenome editors
Maria Silvia Roman Azcona, Yongxing Fang, Antonio Carusillo, Toni Cathomen, Claudio Mussolino

Nature Protocols 15/10
doi: 10.1038/s41596-020-0380-y