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Name: Minyan Li
Academic Background: biochemistry and molecular biology
Workplace: University of Copenhagen, Faculty Of Health and Medical Sciences,
Centre for Glycomics, Department of Cellular and Molecular Medicine, Maersk Building 07-10, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark
Project title: Optimization of gene editing technologies in a human skin model
Project aim: Optimization of gene editing technologies in a human skin model
Supervisor: Hans H. Wandall; Co-supervisor: Ralf Kühn
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Name: Sandra Wimberger
Academic Background: M.Sc in Life Sciences from University of Applied Sciences and Arts Northwestern Switzerland (FHNW)
Workplace: AstraZeneca, Pepparedsleden 1, 431 50 Mölndal, Göteborg, Sverige
Project title: Increase the efficiency of CRISPR/Cas9 mediated knock-in
Project aim: To improve the efficiency of homology directed repair (HDR) and non-homologous end joining (NHEJ) dependent gene knock-in in eukaryotic cells.
Supervisor: Marcello Maresca; Co-supervisor: Radislav Sedlacek, Pinar Akcakaya, Astrazeneca; Marc Pilon, University of Gothenburg
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Name: Nadja Bischoff
Academic Background: First state examination for the teaching profession at secondary schools, University of Freiburg (Germany)
Workplace: BRIC, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark
Project title: Role of epigenetic mechanisms in regulating CRISPR genome editing efficiency
Project aim: Enhance HDR pathway choice by modifying epigenetic marks
Supervisor: Cord Brakebusch Co-supervisor: Claudio Mussolino
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Name: Seren Necla Sevim
Academic Background: Master degree in Biotechnology, Chalmers University of Technology (Sweden) and Bachelor degree in Bioengineering, Ege University (Turkey)
Workplace: Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str.10, 13125 Berlin, Germany
Project title: Enhancing CRISPR/Cas9-induced homology-directed repair (HDR) by targeting the double-strand break (DSB) repair pathway choice
Project aim: To increase precise CRISPR gene editing for gene therapy applications by setting up a traffic light reporter (TLR) system to test repair choice factors (i53, BRCA1) on mouse hematopoietic stem cells and to implement these results for correction of defective gene on mouse disease model
Supervisor: Ralf Kühn; Co-supervisor: Dr. Jochen Welcker, Taconic
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Name: Antonio Carusillo
Academic Background: Molecular and Cell. Biology, University of Bologna (2018)
Workplace: Center for Chronic Immunodeficiency (CCI) - University Medical Center Freiburg
Project title: HDR-CRISPR: a novel system to promote homology directed DNA repair (HDR) using CRISPR
Project aim: to develop novel approaches to increase the frequency of HDR-mediated DNA repair; the success of the project will result in the establishment of a solid platform that will allow for a sharper and safer use of CRISPR/Cas9 as genome editing tool both in basic and applied science.
Supervisor: Claudio Mussolino; Co-supervisor: Cord Brakebusch
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Name: Linn Syding
Academic Background: M.Sc immunology & microbiology both from Uppsala University, Sweden
Workplace: Laboratory of transgenic models of diseases at the Institute of molecular genetics in Vestec, Czech Republic
Project title: In vivo electroporation optimization and rare diseases
Project aim: To optimize the delivery of CRISPR/Cas9 with emphasis on in vivo electroporation. The project also aims to design and carry out a transgenic disease model for Angelman/Prader-Willi syndrome with its subsequent cure
Supervisor: Radislav Sedláček Co-supervisor: Cord Brakebusch and Petr Kašpárek
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Name: Pedro Ramos
Academic Background: BSc is in Biochemistry and MSc in Molecular Genetics and Biomedicine (FCT-UNL, Portugal)
Workplace: IBMC-i3S, University of Porto
Project title: Facilitated genome editing as Responsible Research and Innovation
Project aim: Investigate the predicted harm/risk-benefit and the public acceptance of different applications of CRISPR genome editing.
Supervisor: Anna Olsson Co-supervisor: Cord Brakebusch
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Name: Francesca Tasca
Academic background: Master in Cellular and Molecular Biotechnology (110/110 cum laude) University of Trento, Italy
Workplace: Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, PO box 9600, 2300 RC Leiden, The Netherlands
Project title: Viral-assisted delivery of structurally modified donor DNA and CRISPR-Cas9 nucleases for efficient genome editing
Project aim: Improving gene editing efficiency by adenoviral vector delivery of structurally modified CRISPR-Cas9 nucleases and donor DNA molecules
Supervisor: Manuel A.F.V. Goncalves; Co-supervisor: Marcello Maresca
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